KLONE: An Imbalance-Robust k-NN Ensemble for Cross-Modal Single-Cell Clone Assignment
Xiru Huang, Shengbin Ye, Arlei Silva, Luay Nakhleh
KLONE assigns single-cell RNA-seq cells to DNA-seq identified clones using a k-NN ensemble, achieving high accuracy and minority clone recall in colorectal cancer data.
bioRxiv · Nov 10, 2026 · PreprintBioinformatics