CyclicMPNN: Stable Cyclic Peptide Sequence Generation
Andrew C. Powers, Yanapat Janthana, Parisa Hosseinzadeh
The paper introduces CyclicMPNN, a model that generates energetically stable cyclic peptide sequences by fine-tuning ProteinMPNN with structural and in silico data, improving success rates in folding into generated backbones.
Digital Discovery · Jan 1, 2026Peer-reviewedBiochemistry