Joint probabilistic modeling of pseudobulk and single-cell transcriptomics enables accurate estimation of cell type composition
Simon Grouard, Khalil Ouardini, Yann Rodriguez, Jean‐Philippe Vert, Almudena Espín-Pérez
The paper introduces MixupVI, a deep generative model for reference-free deconvolution of bulk RNA-seq data using single-cell transcriptomics, and releases PyDeconv for benchmarking deconvolution algorithms.
bioRxiv · May 28, 2025 · PreprintBioinformatics