Improved Functional Classification of Hydrolases through Pairwise Structural Similarity of Reaction Cores
Sakib Ferdous, Priyanshu Gupta, Yee Chuen Teoh, Karuna Anna Sajeevan, Vaishnavey SR, Kaelie Hainlin, Nigel Forest Reuel, Abir Z. Qamhiyah, Narayana R. Aluru, Manish Kumar, Ratul Chowdhury
The paper develops a method to classify hydrolase functions using structural similarity of reaction cores, identifying enzyme backbones that can support multiple catalytic activities.
bioRxiv · Jan 9, 2025 · PreprintBioinformatics