The concentric beta-barrel hypothesis for amyloids: Models of soluble and transmembrane amyloid-beta 42 oligomers and channels composed of identical subunits and GM1 gangliosides.
Stewart R. Durell, Yinon Shafrir, H. Robert Guy
The paper develops atomic-scale models of Aβ42 oligomers and transmembrane channels, proposing concentric β-barrel structures and interactions with GM1 gangliosides.
bioRxiv · Mar 23, 2026 · PreprintNeuroscience