Author

Yossef Lerner

Hebrew University of Jerusalem

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Alfredo IacoangeliiD· 2 shared Marc GotkineiD· 2 shared Vivian E. Drory· 2 shared A. Nazlı BaşakiD· 1 shared Ahmad Al KhleifatiD· 1 shared Allison Ann DilliottiD· 1 shared Aminah Ali· 1 shared Ammar Al‐ChalabiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBioinformatics

Alfredo IacoangeliORCID

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2 papers

Recent·Most cited

Exploring transcriptomic and genomic latent variable correction approaches in differential expression analysis.

Yadusayan Appulingam, John Jammal, Aminah Ali, Simon Topp, Hemali P. Phatnani, Justin Kwan, Dhruv Sareen, James R. Broach, Zachary Simmons, Ximena Arcila-Londono, Edward B. Lee, Vivianna M. Van Deerlin, Neil A. Shneider, Ernest Fraenkel, Lyle W. Ostrow, , Oliver Pain

This paper evaluates combining expression-based surrogate variables and genotype-based principal components in differential expression analysis, finding the combined approach improves replicability and biological recall in ALS datasets.

Scientific Reports · Oct 11, 2026Peer-reviewedBioinformatics

The oligogenic structure of amyotrophic lateral sclerosis has genetic testing, counselling, and therapeutic implications

Alfredo Iacoangeli, Allison Ann Dilliott, Ahmad Al Khleifat, Peter Munch Andersen, A. Nazlı Başak, Johnathan Cooper‐Knock, Philippe Corcia, Philippe Couratier, Mamede A. de Carvalho, Vivian E. Drory, Jonathan D. Glass, Marc Gotkine, Yossef Lerner, Orla M. Hardiman, John E. Landers, , Sali M.K. Farhan

The paper investigates oligogenic risk in ALS using genome sequencing data, finding that multiple rare variants in known ALS genes increase disease risk but not clinical outcomes.

Journal of Neurology Neurosurgery & Psychiatry · Feb 13, 2025Peer-reviewedGenetic & Genomic Medicine