PerturbLDM: conditional latent diffusion for modelling single-cell perturbation responses
Lishan Yu, Kang‐Lin Hsieh, Yan Chu, Qizhen Lan, Xingzhong Zhao, Yu-Chun Hsu, Cassidy S Wood, Laila Rasmy, Patrick Glen Pilie, Degui Zhi, Zhongming Zhao, Xiaoqian Jiang, Yulin Dai
PerturbLDM predicts single-cell transcriptional responses to perturbations using a latent diffusion model, outperforming existing methods in drug-dose-cell line combinations and capturing key biological programs.
bioRxiv · Aug 19, 2026 · PreprintBioinformatics