Computational modeling of optogenetic control in human atrial tissue: The role of fibrosis type and illumination strategy
Heqing Zhan, Kaiqi Liu, Chuan’an Wei, Dongdong Deng, Yuanbo Yu
This study uses a computational model to show that fibrosis type and illumination strategy affect optogenetic control of atrial fibrillation, with focal fibrosis requiring larger light areas for termination and diffuse fibrosis allowing efficient disruption with smaller light zones.
bioRxiv · Sep 26, 2025 · PreprintPhysiology