Integrated Proteo-Metabolomics of Urinary Extracellular Vesicles Reveals Early Molecular Divergence and Temporal Pathogenesis of Sepsis-Associated AKI
Tanyu Chang, I‐Lin Tsai, Guan‐Yuan Chen, Te−I Weng, San‐Yuan Wang, Yueh-Chu Sio, Ching-Yi Chen, Li-Yee Hong, I‐Jen Chiu, Yi‐Cheng Lin, Hsi-Hsien Chen, Wei‐Chiao Chang, Mai-Szu Wu, Michael X Chen, C C K Chih-Chin Kao
This study uses longitudinal proteo-metabolomics of urinary extracellular vesicles to identify stage-specific molecular changes in sepsis-associated AKI, revealing early inflammatory and hypoxic responses followed by metabolic reprogramming.
bioRxiv · Jul 24, 2026 · PreprintBiochemistry