Motif-VI Loop Acts as a Nucleotide Valve in the West Nile Virus NS3 Helicase
P. Roy, Z. Walter, L. Berish, H. Ramage, M. McCullagh
This study identifies the motif-VI loop as a nucleotide valve in the West Nile Virus NS3 helicase, showing its role in ATP hydrolysis and viral replication through molecular simulations and experimental validation.
bioRxiv · Nov 30, 2023Biochemistry