Accurate cross-platform GWAS analysis via two-stage imputation
Anya Greenberg, Kaylia M. Reynolds, Zhanqing Hua, Michelle T. McNulty, Matthew Gordon Sampson, Hyun M. Kang, Dongwon Lee
This paper introduces TSIM, a two-stage imputation method for GWAS that harmonizes heterogeneous genotyping data, controlling errors and replicating known associations without false positives.
medRxiv · Apr 19, 2024 · PreprintGenetic & Genomic Medicine