Myofibroblast lineage mapping and inhibiting subretinal fibrosis by targeting SMAD3 and MRTF pathways via microRNA-24 functional study
Yinga Wu, Yao Tong, Katherine G. Byrnes, Qi Zhou, Chunmin Dong, Chase Benjamin, Emma Parker, Duran Bao, Zhaoyang Ren, Chastain A. Anderson, Rafael L. Ufret-Vincenty, Yu-Guang He, Ze Zhang, David M. Hinkle, Jing Ma, Shusheng Wang
The paper identifies multiple cell lineages contributing to myofibroblasts in subretinal fibrosis and shows that miR-24 regulates pathways involved in fibrosis, with SMAD3 and MRTF inhibitors showing therapeutic potential.
bioRxiv · Jun 27, 2026 · PreprintMolecular Biology