Deletion of Cd248 in Postn positive myofibroblast Fails to Attenuate Cardiac Remodeling and Fibrosis in a Murine Model of Pressure-Overload Cardiomyopathy
Donghua Li, Dongmei Zhong, Tian Tan, Zhilei Huang, Mingyue Wu, Yongshan Liu, Yalin Zhang, Chen Liu, Fu-Li Xiang, Jie Xu
This study tests if deleting Cd248 in Postn+ myofibroblasts reduces cardiac fibrosis in pressure-overload cardiomyopathy, but finds no significant improvement in cardiac function or fibrosis.
bioRxiv · Sep 26, 2025 · PreprintPathology