VEGFA+ macrophages promote the growth and metastasis of intrahepatic cholangiocarcinoma via OSM and THBS1 signaling
Tingjie Wang, Ruitao Long, Zhongyu Cheng, Mi Zhang, Bing Wei, Congmin Lyu, Chuanrui Xu
This study identifies VEGFA+ macrophages in ICC that promote tumor growth and metastasis through OSM and THBS1 signaling, with dual blockade showing therapeutic potential.
bioRxiv · Oct 2, 2025 · PreprintCancer Biology