Reconciling Cooperativity Definition in PROTACs and Molecular Glues: Thermodynamic Dissection into PPI and Ligand Entropic Contributions
Xuan Cao, Yang Li, Zuohang Qu, Lizhi Jiang, Lijing Tang, Haomin Chen
The paper analyzes thermodynamic contributions to cooperativity in PROTACs and molecular glues, revealing entropic penalties from ligand exposure and reconciling conflicting definitions.
bioRxiv · Feb 9, 2026 · PreprintBiochemistry