Wiz regulates clustered protocadherin genes by restricting CTCF/cohesin loop extrusion in a genomic-distance biased manner
Tianjie Li, Jingwei Li, Leyang Wang, Haiyan Huang, Qiang Wu
The paper introduces COP, a deep learning framework to predict ZFP genomic enrichments, identifies Wiz as a key regulator of cPcdh genes by affecting CTCF/cohesin loop extrusion.
PLoS Genetics · Jul 16, 2026Peer-reviewedCell Biology