Cancer BiologybioRxivPreprint
Histopathology-inferred spatial transcriptomics characterizes the tumor microenvironment in 1,500 head and neck tumors and predicts clinical outcomes
Sumona Biswas, Sumeet Patiyal, T W Chen…·Eytan Ruppin
This paper develops HEiST, a deep learning method to infer spatial transcriptomes from H&E slides, identifies two prognostic Spatiotypes in HNSC, and shows they predict treatment response better than existing biomarkers.
DOI 10.64898/2026.05.16.725687