GenomicsbioRxivPreprint
Combinatorial MAPK states drive opposing gene programmes: a reanalysis of MAP3K-driven transcriptional responses in MCF10A cells
Mireia Solé, Beatriz Candás‐Estébanez, Renata Kelly da Palma…·Albert Gubern
The paper reanalyzes RNA-seq data to show that JNK co-activation with ERK drives E2F/MYC transcriptional activation, explaining a 10-fold difference in cell cycle entry compared to ERK-only activation.
DOI 10.64898/2026.07.10.737700