Discovering pathways through ribozyme fitness landscapes using information theoretic quantification of epistasis
Nathaniel Charest, Yuning Shen, Yei‐Chen Lai, Irene A. Chen, Joan‐Emma Shea
The paper uses information theory to model epistasis in ribozymes, predicting high-activity mutants that were validated experimentally and revealed an evolutionary bridge between ribozyme families.
RNA · Aug 14, 2023Peer-reviewedSystems Biology