Repurposed macroH2A Chromatin Landscapes Guide Cellular Reprogramming
Dimitrios Valakos, Antonis Kokkalis, Eleftheria Klagkou, Alexander Polyzos, Giannis Vatsellas, Dimitris Thanos
This study shows that macroH2A1 nucleosomes switch roles during cellular reprogramming from inhibiting to facilitating pluripotency by reshaping the chromatin landscape.
bioRxiv · Dec 12, 2025 · PreprintMolecular Biology