CIRPIN: Learning Circular Permutation-Invariant Representations to Uncover Putative Protein Homologs
Aiden R. Kolodziej, S. Mazdak Abulnaga, Sergey Ovchinnikov
CIRPIN identifies protein homologs related by circular permutation using a permutation-invariant graph neural network, uncovering thousands of novel pairs and revealing natural PDZ domain permutations.
bioRxiv · Nov 18, 2025 · PreprintBiophysics