NeurosciencebioRxivPreprint
Connectome Principal Component Drives Cross-Dataset Replication and Clinical Prediction in Symptom Lesion Network Mapping
Sasin Treeratana, Arp‐Arpa Kasemsantitham, Setthanan Jarukasemkit…·Chaipat Chunharas
This study shows that symptom lesion network mapping (sLNM) results are biased toward the first principal component of the normative connectome, leading to spurious convergence and non-specific clinical predictions, which can be corrected by controlling for PC1.