LieOTMap: A Differentiable Approach to Cryo-EM Fitting via Lie-Theoretic Optimal Transport
Yue Hu, Zanxia Cao, Yingchao Liu
LieOTMap fits high-resolution atomic models into cryo-EM maps using a differentiable framework based on Lie algebra and optimal transport, achieving accurate alignment of E. coli GroEL.
bioRxiv · Sep 16, 2025 · PreprintBioinformatics