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Ambient Proteins: Training Diffusion Models on Low Quality Structures
Giannis Daras, Jeffrey Ouyang-Zhang, Krithika Ravishankar…·Daniel J. Diaz
Treating low-confidence AlphaFold structures as noisy data at pLDDT-dependent diffusion times lets a 16.7M-parameter model generate long proteins with higher diversity, designability and novelty than Proteína.