Quantifying the contribution of DNA conformational flexibility to transcription factor binding on nucleosomal DNA uncovers indirect readout across diverse TF families
Upalabdha Dey, Gustavo Sganzerla Martinez, Ravi Kumar, Venkata Rajesh Yella, Aditya Arun Kumar
The paper develops DNAflexpy to quantify DNA conformational flexibility and shows it improves TF binding prediction on nucleosomes, revealing indirect readout mechanisms across TF families.
bioRxiv · May 21, 2025 · PreprintBioinformatics