Microcystin-LR aerosol exposure increases inflammatory drivers of asthma, Evidence of an NF-κB amplification mechanism
Joshua D. Breidenbach, Bivek Timalsina, Benjamin W. French, Lauren M. Stanoszek, John‐Paul Lavik, Irum Syed, Upasana Shrestha, Andrew L. Kleinhenz, Apurva Chandrakant Lad, Prabhatchandra R. Dube, Shungang Zhang, Dhilhani Faleel, Ronald Mark Wooten, James C. Willey, Jeffrey R. Hammersley, , David J. Kennedy
This study shows that microcystin-LR aerosol exposure worsens asthma symptoms and inflammation in mice and human airway models through an NF-κB amplification mechanism.
bioRxiv · Sep 13, 2025 · PreprintMolecular Biology