Genetic variants in TMPRSS2 and Structure of SARS-CoV-2 spike glycoprotein and TMPRSS2 complex
Ravikanth Vishnubhotla, Naveen Vankadari, Vijayasarathy Ketavarapu, Ramars Amanchy, Steffie Urmila Avanthi, Govardhan Bale, D. Nageshwar Reddy, Mitnala Sasikala
The paper identifies a TMPRSS2 variant that may hinder SARS-CoV-2 entry and reports the structure of TMPRSS2 in complex with the spike glycoprotein and protease inhibitors.
bioRxiv · Jun 30, 2020 · PreprintGenetics