Estrogen regulation and functional role of FGFR4 in estrogen receptor positive breast cancer
Kai Ding, Lyuqin Chen, Kevin M. Levine, Matthew J. Sikora, Nilgun Tasdemir, David J. Dabbs, Rachel Catherine Jankowitz, Rachel B. Hazan, Osama Shiraz Shah, Jenny Atkinson, Adrian V. Lee, Steffi Oesterreich
This study investigates FGFR4's role in endocrine resistance in ER+ breast cancer and finds it does not generally mediate resistance, though HER2-like subtypes may respond to FGFR4 inhibition.
Breast Cancer Research and Treatment · Mar 17, 2025Peer-reviewedCancer Biology