GenomicsbioRxivPreprint
De novo distillation of thermodynamic affinity from deep learning regulatory sequence models of in vivo protein-DNA binding
Amr M. Alexandari, Connor A. Horton, Avanti Shrikumar…·Anshul Bharat Kundaje
The paper introduces Affinity Distillation (AD), a method to extract thermodynamic affinities from deep learning models of in vivo TF binding, showing it outperforms motif-based methods in predicting sequence variation impacts.