Complex relationship among vessel diameter, shear stress and blood pressure controlling vessel pruning during angiogenesis
Vivek Kumar, Prashant Kumar, Takao Hikita, Mingqian Ding, Yukinori Kametani, Masanori Nakayama, Yosuke Hasegawa
The paper develops a predictive model for vessel pruning during angiogenesis using machine learning, finding that shear stress, blood pressure, and vessel radius are tightly correlated with pruning sites.
PLoS Computational Biology · Jan 12, 2026Peer-reviewedDevelopmental Biology