Dirichlet distribution parameter estimation with application in microbiome analyses
Daniel T. Fuller, Sumona Mondal, Shantanu Sur, Nabendu Pal
This paper proposes using the Dirichlet distribution to model microbiome relative abundances and compares estimation methods, finding that Dirichlet MLE is computationally efficient and comparable to BDME.
Statistics in Medicine · Feb 1, 2026Peer-reviewedBioinformatics