Author

Y. B. Huang

University of PennsylvaniaORCID 0000-0002-0246-9801Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:benchmark study· 1 Research Focus:benchmarking· 1 Approach:statistical model· 1

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Hanzhi WangiD· 1 shared Parker C. WilsoniD· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperBioinformatics

Hanzhi WangORCID

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1 paper

Recent·Most cited

BioinformaticsbioRxivPreprintAug 24, 2026

Virtual-cell models compress unseen intervention geometry through a target-specific generalization bottleneck

Y. B. Huang, Hanzhi Wang, Parker C. Wilson

The paper identifies Intervention Geometry Compression (IGC) in virtual-cell models, showing that high state similarity can mask loss of perturbation relationships, and proposes empirical anchoring to improve generalization.

DOI 10.64898/2026.08.21.746243

statistical modelbenchmark study