Quantifying the effect of experimental perturbations at single-cell resolution
Daniel B. Burkhardt, Jay S. Stanley, Alexander Tong, Ana Luisa Perdigoto, Scott Gigante, Kevan C. Herold, Guy Wolf, Antonio J. Giráldez, David van Dijk, Smita Krishnaswamy
This paper introduces a method to quantify perturbation effects at single-cell resolution using manifold-based likelihood estimation and vertex frequency clustering, achieving higher accuracy than existing methods.
Nature Biotechnology · Feb 8, 2021Peer-reviewedBioinformatics