Shiwei Sun

This study shows NPC1L1 inhibits osteogenesis and promotes osteoporosis by regulating cholesterol metabolism through the C/EBP/Cyp27a1/27-OHC axis.

ProDESIGN-LE designs protein sequences efficiently by learning residue local environments, achieving high accuracy in structure prediction and experimental validation.

ProALIGN improves protein structure prediction by learning optimal sequence-template alignments using deep learning, outperforming existing methods on multiple datasets.