Convergent genetic adaptation in human tumors developed under systemic hypoxia and in populations living at high altitudes
Carlota Arenillas, Lucía Celada, José Ruiz-Cantador, Bruna Calsina, Debayan Datta, Eduardo García‐Galea, Roberta Fasani, Ana Belén Moreno-Cárdenas, Juan José Alba‐Linares, Berta Miranda, Ángel M. Martínez‐Montes, Cristina Álvarez-Escolá, Beatriz Lecumberri S., Ana González García, Shahida K. Flores, , Rodrigo Almeida Toledo
This study links EPAS1HIF2 genetic adaptations in high-altitude populations to similar mutations in hypoxia-driven tumors, showing shared mechanisms in hypoxia response and tumorigenesis.
Cancer Discovery · Apr 8, 2025Peer-reviewedCancer Biology