Causal roles of phenotypic age and metabolic health on dementia: a Mendelian randomisation and structure learning study
Alexandra Baousi, Katrina Dobinda, Jingqi Zhu, Xinzhu Yu, Kenneth Ross Muir, Artitaya Lophatananon, Brian McMillan, Paul Clarkson, Eugene Yee Hing Tang, Hui Guo
This study uses Mendelian randomisation and causal network analysis to evaluate the causal effects of phenotypic age acceleration and metabolic health on dementia, finding no evidence of a causal effect but identifying key biomarkers.
medRxiv · Sep 3, 2026 · PreprintGenetic & Genomic Medicine