Enhanced fluorescence lifetime imaging microscopy denoising via principal component analysis
Soheil Soltani, JN Paulson, Emma J. Fong, Shannon M. Mumenthaler, Andrea M. Armani
This paper introduces NC-PCA, a noise-corrected principal component analysis method for FLIM denoising, showing it reduces uncertainty 4-fold and identifies multiple metabolic states in colorectal cancer organoids.
bioRxiv · Feb 26, 2025 · PreprintBioengineering