Author

Lisa J. McReynolds

National Institutes of HealthORCID 0000-0002-1018-1453Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Approach:benchmark study· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1 Research Focus:polygenic risk· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Marc D. TischkowitziD· 2 shared Neelam GiriiD· 2 shared Adam Nelson· 1 shared Agata SmogorzewskaiD· 1 shared Aimee L. DavidsoniD· 1 shared Alexander GuseviD· 1 shared Alexander J.M. DingemansiD· 1 shared Amanda B. SpurdleiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Marc D. TischkowitzORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Genomic ascertainment of PALB2-related cancer predisposition

Douglas R. Stewart, Jung Gil KIM, Jeremy S. Haley, Jiang Li, Michael R. Sargen, Hyokyoung Grace Hong, Marc D. Tischkowitz, Lisa J. McReynolds, David J. Carey

This study evaluates cancer risk and mortality in individuals with PALB2 pathogenic variants using genomic data from two cohorts, finding increased cancer odds and mortality.

medRxiv · Apr 4, 2026 · PreprintGenetic & Genomic Medicine

Polygenic modifiers of expressivity in telomere biology disorders

Michael Poeschla, Uma P. Arora, Amanda J. Walne, Lisa J. McReynolds, Marena Rebekka Niewisch, Neelam Giri, Logan P Zeigler, Alexander Gusev, Mitchell J. Machiela, Hemanth Tummala, Sharon A. Savage, Vijay G. Sankaran

This study identifies polygenic modifiers of expressivity in telomere biology disorders by showing how common and rare genetic variants interact to influence clinical variability.

Journal of Clinical Investigation · Jun 3, 2025Peer-reviewedGenetic & Genomic Medicine

Analysis of BRCA1, BRCA2 and PALB2 related Fanconi anemia identifies scope to expand disease phenotypic features and predict breast cancer risk in heterozygotes

Sharon E. Johnatty, Emma Tudini, Michael T. Parsons, Kyriaki Michailidou, Maria Zanti, Daffodil M. Canson, Aimee L. Davidson, Tamar R. Berger, Rasim Özgür Rosti, Christian Peter Kratz, Reinhard Kalb, Lisa J. McReynolds, Neelam Giri, Marcy E. Richardson, Tina F. Pesaran, , Amanda B. Spurdle

medRxiv · May 25, 2025 · PreprintGenetic & Genomic Medicine