Genetic & Genomic MedicinemedRxivPreprint
Mendelian randomization confirms the role of Y-chromosome loss in Alzheimer's Disease etiopathogenesis in males
Pablo García‐González, Itziar de Rojas, Sonia Moreno–Grau…·Agustı́n Ruiz
This study uses Mendelian randomization to show that genetic risk for mosaic loss of chromosome Y (mLOY) increases AD risk in males, but not females, suggesting mLOY directly contributes to AD pathogenesis.
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