A Robust Framework for Predicting Mutation Effects on Transcription Factor Binding: Insights from Mutational Signatures in 560 Breast CancerGenomes
Hüseyin Hilmi Kılınç, Burçak Otlu
The paper develops a framework to predict mutation effects on transcription factor binding using mutational signatures in breast cancer genomes, revealing subtype-specific rewiring of gene regulatory networks.
bioRxiv · Feb 17, 2026 · PreprintBioinformatics