Christy J. Vander Jagt

Mutant alleles differentially shape cattle complex traits and fitness

The paper investigates the effects of classical mutant alleles on cattle complex traits and fitness, finding differential impacts on fertility, stature, milk production, and mastitis risk.

Demographic history, cold adaptation, and recent NRAP recurrent convergent evolution at amino acid residue 100 in the world northernmost cattle from Russia

The paper investigates the evolutionary history and adaptation of two northern Russian cattle breeds, identifying a convergent mutation in NRAP associated with cold adaptation.

Quantifying the contribution of sequence variants with regulatory and evolutionary significance to 34 bovine complex traits

The paper identifies sequence variants with regulatory and evolutionary significance in cattle and ranks them using a Functional-And-Evolutionary Trait Heritability score to improve genomic prediction.

Genome-wide profiling of microRNAs and prediction of mRNA targets in 17 bovine tissues

This study identifies microRNA expression and target sites in 17 bovine tissues, revealing tissue-specific regulation and genomic features of microRNA-target interactions.

Genome variants associated with RNA splicing variation in bovine are extensively shared between tissues

The paper identifies bovine sQTLs associated with RNA splicing variation and shows they are shared across tissues and linked to complex traits.

Putative bovine topological association domains and CTCF binding motifs can reduce the search space for causative regulatory variants of complex traits

The paper maps bovine TADs and CTCF binding motifs using genomic synteny and shows they reduce the search space for regulatory variants associated with complex traits.