Towards interpretable molecular and spatial analysis of the tumor microenvironment from digital histopathology images with HistoTME-v2
Sushant Patkar, Timothy R. Rosean, Palak G. Patel, Stephanie A. Harmon, Peter L. Choyke, Tamara Jamaspishvili, Barış Türkbey
HistoTME-v2 predicts cell type-specific transcriptomic signatures and spatial distributions from H&E images, outperforming baselines across 25 tumor types and multiple validation datasets.
bioRxiv · Jun 11, 2025 · PreprintPathology