Guibing Guo

The paper compares sequence-based and structure-based methods for predicting protein function, finding that structure-based approaches can offer better accuracy when using high-quality protein structures.

FunGeneTyper is a deep learning framework for ultra-accurate classification and discovery of functional genes in microbiomes, outperforming existing methods in multiple environments.

This study shows that pre-trained protein language models can predict mutation pathogenicity and patient survival in cancer, outperforming existing methods.