GLUCURONIDATION: THE LAST DEFENSIVE LINE AGAINST BILEACID TOXICITY DURING CHOLESTASIS.
Jocelyn Trottiet, Audrey-Anne Lavoie, Mélanie Verreault, Ewa Wunsch, Robert J. Straka, Nisanne S. Ghonem, Piotr Milkiewicz, Olivier Barbier
This study evaluates glucuronidation's role in protecting liver cells during cholestatic conditions by analyzing BA-G accumulation and UGT enzyme expression in response to bile acids and their agonists.
bioRxiv · Aug 23, 2025 · PreprintPharmacology & Toxicology