EVIDENCE FOR ANGIOTENSIN II AS A NATURALLY EXISTING SUPPRESSOR FOR THE NATRIURETIC PEPTIDE SYSTEM
Xiao Ma, Seethalakshmi R. Iyer, Xiaoyu Ma, Shawn Reginauld, Yang Chen, Shuchong Pan, Ye Zheng, Dante G. Moroni, Yue Yu, Lianwen Zhang, Valentina Cannone, Horng H. Chen, Carlos Maria Ferrario, S. Jeson Sangaralingham, John C. Jr Burnett
This study provides evidence that angiotensin II suppresses the natriuretic peptide system by inhibiting cGMP production via AT1 receptor and PKC, supporting dual-targeting therapies for cardiovascular disease.
bioRxiv · Jan 26, 2023 · PreprintMolecular Biology