Spatial immune architecture and tumor lineage programs jointly shape clinical outcomes in advanced pancreatic ductal adenocarcinoma
Hay Mar Oo, Tauangtham Anekpuritanang, Napat Angkathunyakul, Ufuk Degirmenci, Ananya Pongpaibul, Siwakorn Punyawatthananukool, Krittiya Korphaisarn, Somponnat Sampattavanich
This study combines spatial proteomics and transcriptomics in advanced PDAC to show that tumor lineage states and immune architecture are linked to clinical outcomes, with a new spatial immune score improving prognostic accuracy.
bioRxiv · Jul 4, 2026 · PreprintCancer Biology