Chronic pharmacologic manipulation of dopamine transmission ameliorates metabolic disturbance in syndrome caused by mutated trappc9
Yán Li, Muhammad Usman, Ellen Sapp, Yuting Ke, Zejian Wang, Adel Boudi, Marian DiFiglia, Xueyi Li
This study shows that trappc9 loss-of-function causes obesity and NAFLD by disrupting dopamine transmission, which can be mitigated with dopamine receptor modulators.
bioRxiv · Feb 13, 2024 · PreprintNeuroscience