Left ventricular transcriptome and extracellular vesicle-derived miRNAs in porcine donation after circulatory death (DCD) hearts undergoing prolonged working mode ex situ perfusion
Fulin Wang, Eliana Lucchinetti, Phing‐How Lou, Darren H. Freed, Michael Zaugg
The paper identifies transcriptional changes in porcine DCD hearts during prolonged ESHP and shows cardioprotection reduces maladaptive gene expression and increases beneficial miRNA release.
The Journal of Heart and Lung Transplantation · Dec 27, 2025Peer-reviewedMolecular Biology