Systematic comparative analysis of Mendelian randomization methods for inferring causal genes of complex phenotypes and the application to psychiatric diseases
Lin Jiang, Guorong Yi, Xiangyi Li, Chao Xue, Mulin Jun Li, Hailiang Huang, Miaoxin Li
This study compares multiple Mendelian randomization methods for causal gene inference in complex phenotypes, identifies two robust methods, and applies them to psychiatric diseases to discover known and novel causal genes.
bioRxiv · Nov 9, 2020 · PreprintBioinformatics