Targeting of immune cells by human adenoviruses: CD46 receptor density influences entry of chimaeric Ad5F35 into natural killer cells
Tyler Barr, Elif Aktar, Sian L. Drake, Magdalena Karwatka, Erica Wilson, Ruth Hughes, George Eric Blair, Graham P. Cook
This study shows that CD46 receptor density affects Ad5F35 transduction efficiency, with lower density requiring higher viral particle numbers for equivalent transduction in NK cells compared to epithelial cells.
bioRxiv · Jun 10, 2026 · PreprintMolecular Biology